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化合物

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规格

ST-SM-076

A66

1166227-08-2

a potent and specific p110α inhibitor with IC50 of 32 nM.

规格:5mg      10mg      50mg


ST-SM-042

ABT-263 (Navitoclax)

923564-51-6

a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM, and ≤1 nM, respectively.

规格:5mg    10mg    25mg


 

ST-SM-031

AC480 (BMS-599626)

714971-09-2

a selective and potent inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM respectively.

规格:5mg    25mg


ST-SM-030

Afatinib (BIBW2992)

439081-18-2

 irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively.

规格:5mg    10mg


ST-SM-039

Alectinib (CH5424802)

1256580-46-7

a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation.

规格:5mg    10mg    50mg


ST-SM-082

Alisertib (MLN8237)

1028486-01-2

 a selective Aurora A inhibitor with IC50 of 1.2 nM.

规格:5mg      10mg      50mg


ST-SM-064

Azacitidine

320-67-2

specifically inhibits DNA methylation by trapping DNA methyltransferases.

规格:50mg

ST-SM-077

BEZ235(NVP-BEZ235)

915019-65-7

a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM, respectively. Inhibits ATR with IC50 of 21 nM.

规格:50mg      100mg

ST-SM-078

BKM120 (NVP-BKM120, Buparlisib)

944396-07-0

 a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively.

规格:5mg      10mg

ST-SM-054

Bortezomib (PS-341)

179324-69-7

a potent 20S proteasome inhibitor with Ki of 0.6 nM.

规格:5mg     25mg

ST-SM-023

BIO

667463-62-9

 a specific inhibitor of GSK-3α/β with IC50 of 5 nM, which activates Wnt signaling pathway.

规格:10mg    50mg

ST-SM-036

Cabozantinib (XL184, BMS-907351)

849217-68-1

a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.

规格:5mg    10mg    50mg

ST-SM-079

CAL-101 (Idelalisib, GS-1101)

870281-82-6

a selective p110δ inhibitor with IC50 of 2.5 nM.

规格:10mg      50mg

ST-SM-056

Carfilzomib(PR171)

868540-17-4

an irreversible proteasome inhibitor with IC50 of <5 nM.

规格:5mg     10mg    50mg

ST-SM-040

Ceritinib (LDK378)

1032900-25-6

a potent inhibitor against ALK with IC50 of 0.2 nM.

规格:5mg    50mg

ST-SM-002

CHIR99021

252917-06-9

a potent, ATP-competitive & highly selective GSK-3 inhibitor,  which inhibits GSK-3α and GSK-3β with IC50 of 10 nM and 6.7 nM, respectively

规格:2mg    5mg    25mg

ST-SM-034

Crizotinib (PF2341066)

877399-52-5

a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectively.

规格:5mg    10mg    50mg

ST-SM-069

Dabrafenib(GSK2118436)

1195765-45-7

a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively.

规格:5mg    10mg    20mg

 

ST-SM-057

DAPT (GSI-IX)

208255-80-5

an inhibitor of γ-secretase and Notch, a γ-secretase substrate

规格:5mg     10mg    25mg

 

ST-SM-038

Dasatinib

302962-49-8

a novel, potent and multi-targeted inhibitor of Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively.

规格:25mg

ST-SM-063

Decitabine

2353-33-5

a potent inhibitor of DNA methylation.

规格:10mg     25mg     50mg

ST-SM-025

Dorsomorphin 2HCl

1219168-18-9

a potent and selective inhibitor of ATR kinase with IC50 of 5 nM

规格:10mg    50mg

ST-SM-074

Doxorubicin (Adriamycin)

25316-40-9

an antibiotic agent and a DNA intercalator that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells

规格:10mg     25mg

ST-SM-021

Everolimus (RAD001)

159351-69-6

an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.

规格:10mg    25mg

ST-SM-028

Erlotinib HCl (OSI-744)

183321-74-6

 an EGFR inhibitor with IC50 of 2 nM.

规格:100mg    500mg

ST-SM-050

Fludarabine

21679-14-1

a STAT1 activation inhibitor and a DNA synthesis inhibitor.

规格:5mg    10mg    25mg

ST-SM-011

GDC0941

957054-30-7

a potent inhibitor of PI3Kα/δ with IC50 of 3 nM

规格:5mg    10mg    50mg

ST-SM-018

Gefitinib

184475-35-2

an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively

规格:100mg    250mg

ST-SM-032

Imatinib (STI571)

152459-95-5

a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively

规格:250mg    500mg

ST-SM-001

IWR-1-endo

1127442-82-3

a Wnt/β-catenin inhibitor with an IC50 value of 180 nM.

规格:5mg    10mg

ST-SM-010

(+)-JQ-1

1268524-70-4

a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2)

规格:10mg    25mg

ST-SM-029

Lapatinib

231277-92-2

a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.

规格:25mg    100mg

ST-SM-003

LDN193189

1062368-24-4

a selective BMP signaling inhibitor,with IC50 of 5 nM and 30 nM for inhibition of the BMP type I receptors ALK2 and ALK3, respectively

规格:2mg    5mg

ST-SM-044

Lenalidomide (CC-5013)

191732-72-6

 a TNF-α secretion inhibitor with IC50 of 13 nM.

规格:10mg


ST-SM-007

LY2157299

700874-72-2

 a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM

规格:5mg    10mg

ST-SM-012

LY411575

209984-57-6

 a potent γ-secretase inhibitor with IC50 of 0.082 nM, which inhibits Notch cleavage with IC50 of 0.39nM

规格:10mg    50mg

ST-SM-017

LY294002

154447-36-6

 an inhibitor of PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM respectively

规格:10mg    25mg

ST-SM-055

MG132

133407-82-6

an inhibitor of proteasome with IC50 of 100 nM in a cell-free assay, and also inhibits calpain with IC50 of 1.2 μM.

规格:5mg     25mg    100mg

ST-SM-086

Mitomycin C

50-07-7

an antineoplastic antibiotic by inhibiting DNA synthesis.

规格:10mg      50mg      200mg

ST-SM-051

MK2206

1032350-13-2

 a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM.

规格:5mg    10mg    25mg

 

ST-SM-061

ML324

1222800-79-4

a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM.

规格:10mg     50mg

ST-SM-052

Nilotinib (AMN-107)

641571-10-0

a Bcr-Abl inhibitor with IC50<30 nM.

规格:25mg    100mg

ST-SM-033

Nintedanib (BIBF 1120)

928326-83-4

 a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM respectively.

规格:5mg    10mg    50mg


ST-SM-013

NUTLIN 3

890090-75-2

 a potent and selective Mdm2 (a ubiquitin protein ligase for p53) antagonist with IC50 of 90 nM

规格:5mg    10mg    25mg


ST-SM-060

Olaparib (AZD2281, KU0059436)

763113-22-0

a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM.

规格:10mg     25mg    100mg

ST-SM-053

Paclitaxel

33069-62-4

a chemo drug and a microtubule polymer stabilizer with IC50 of 0.1 pM

规格:10mg    50mg


ST-SM-072

Palbociclib (PD-0332991) HCl

827022-32-2

 a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM, respectively.

规格:5mg     10mg

ST-SM-059

Panobinostat (LBH589)

404950-80-7

a broad-spectrum HDAC inhibitor with IC50 of 5 nM.

规格:10mg     50mg

 

ST-SM-080

Pazopanib

444731-52-6

a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.

规格:25mg      100mg

ST-SM-083

PD-1/PD-L1 inhibitor 1

1675201-83-8

disrupts PD-1/PDL-1 interaction.

规格:5mg      25mg

ST-SM-014

PD0325901

391210-10-9

a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM

规格:5mg    25mg


ST-SM-015

PD173074

219580-11-7

a potent FGFR1 inhibitor with IC50 of ~25 nM, which also inhibits VEGFR2 with IC50 of 100-200 nM

规格:5mg    10mg

ST-SM-067

PD98059

167869-21-8

a non-ATP competitive MEK inhibitor with IC50 of 2 μM.

规格:5mg    10mg

ST-SM-073

Pemetrexed

150399-23-8

an antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.

规格:10mg     50mg

ST-SM-019

Rapamycin(sirolimus )

53123-88-9

a specific mTOR inhibitor with IC50 of ~0.1 nM

规格:5mg    25mg

ST-SM-047

Regorafenib(BAY73-4506)

755037-03-7

a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.

规格:25mg

ST-SM-016

RG108

48208-26-0

DNA methyltransferase Inhibitor with IC50 of 115 nM

规格:10mg    50mg

ST-SM-043

RITA (NSC 652287)

213261-59-7

induces DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53.

规格:5mg    10mg

ST-SM-006

SAG

912545-86-9

A potent agonist of Hedgehog (Hh)/Smoothened(Smo) signalling with EC50 of 3nM

规格:2mg    5mg

ST-SM-070

SB203580

152121-47-6

a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and it blocks PKB phosphorylation with IC50 of 3-5 μM.

规格:25mg    50mg    100mg

ST-SM-004

SB431542

301836-41-9

 a potent and selective inhibitor of ALK5 with IC50 of 94 nM

规格:10mg    50mg

ST-SM-026

Sorafenib Tosylate

284461-73-0

a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively

规格:5mg    10mg    50mg

ST-SM-071

SP600125

129-56-6

 a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM, respectively.

规格:10mg    50mg

ST-SM-027

Sunitinib Malate

341031-54-7

a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, which also inhibits c-Kit.

规格:100mg

ST-SM-037

SSR128129E

848318-25-2

an allosteric and selective FGFR1 inhibitor with IC50 of 1.9 μM.

规格:5mg    20mg

 

ST-SM-022

Tacrolimus (FK506)

104987-11-3

 binds to the immunophilin FKBP12; inhibits PP2B (calcineurin); reduces peptidyl-prolyl isomerase activity in T cells.

规格:50mg    100mg

ST-SM-045

Thalidomide

50-35-1

Thalidomide inhibits an E3 ubiquitin ligase in CRBN-DDB1-Cul4A complex. It inhibits TNF α biosynthesis and bFGF-induced angiogenesis. It also induces apoptosis in human monocyte cultures, and suggested to inhibit HIV-1 replication.

规格:200mg

ST-SM-049

Tofacitinib citrate(CP690550)

540737-29-9

 a potent and selective inhibitor of JAK3 with IC50 of 1 nM.

规格:5mg    25mg

ST-SM-065

Trametinib (GSK1120212)

871700-17-3

 a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM.

规格:5mg    10mg

ST-SM-066

U0126-EtOH

1173097-76-1

a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM.

规格:25mg    100mg

ST-SM-068

Vemurafenib (PLX4032, RG7204)

918504-65-1

a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM.

规格:10mg    50mg

ST-SM-041

Venetoclax (ABT-199, GDC-0199)

1257044-40-8

a Bcl-2-selective inhibitor with Ki of <0.01 nM.

规格:5mg    50mg

ST-SM-008

Vismodegib(GDC0449)

879085-55-9

a potent and specific inhibitor of Hedgehog (Hh)/Smoothened(Smo) signaling with IC50 of 3nM

规格:5mg    10mg

ST-SM-058

Vorinostat (suberoylanilide hydroxamic acid, SAHA)

149647-78-9

 an HDAC inhibitor with IC50 of ~10 nM.

规格:200mg     500mg


ST-SM-081

XAV-939

284028-89-3

a selective inhibitor of Wnt/β-catenin signaling through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM.

规格:10mg      25mg    50mg

ST-SM-005

Y27632 2hcl

129830-38-2

a selective Rho-kinase inhibitor

规格:2mg    5mg    10mg

ST-SM-046

YM155

781661-94-7

 a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM, also slightly inhibits the interaction of Survivin with XIAP.

规格:5mg    10mg    25mg

ST-SM-020

ZSTK-474

475110-96-4

an inhibitor of class I PI3K isoforms,  mostly PI3Kδ, with IC50 of 37 nM

规格:10mg    50mg


医诺生物提供生物医学研究中最常用的八十余种小分子化合物。 


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